diff --git a/runtime/lua/vim/filetype/detect.lua b/runtime/lua/vim/filetype/detect.lua
index 1b624b7022..1680c316bf 100644
--- a/runtime/lua/vim/filetype/detect.lua
+++ b/runtime/lua/vim/filetype/detect.lua
@@ -2162,6 +2162,10 @@ local function match_from_hashbang(contents, path, dispatch_extension)
     end
   end
 
+  if name == 'uv' and matchregex(first_line, [[\<uv run\>]]) then
+    return 'python'
+  end
+
   -- If nothing matched, check the extension table. For a hashbang like
   -- '#!/bin/env foo', this will set the filetype to 'fooscript' assuming
   -- the filetype for the 'foo' extension is 'fooscript' in the extension table.
diff --git a/test/old/testdir/test_filetype.vim b/test/old/testdir/test_filetype.vim
index 5d42d65e43..ae2afec370 100644
--- a/test/old/testdir/test_filetype.vim
+++ b/test/old/testdir/test_filetype.vim
@@ -1106,7 +1106,8 @@ func s:GetScriptChecks() abort
       \ 'php': [['#!/path/php']],
       \ 'python': [['#!/path/python'],
       \            ['#!/path/python2'],
-      \            ['#!/path/python3']],
+      \            ['#!/path/python3'],
+      \            ['#!/usr/bin/env -S uv run --script']],
       \ 'groovy': [['#!/path/groovy']],
       \ 'ruby': [['#!/path/ruby']],
       \ 'javascript': [['#!/path/node'],